Every athlete knows the effect of aromatization. This is the process of converting substances with high androgenic activity to oestrogens. To put it more simply, almost all steroids are based on testosterone derivatives – the male sex hormone. Therefore, each of these drugs has a certain degree of androgenic activity.
This entails a sharp increase of female hormones (oestrogens) in the male body, which leads to unpleasant side effects. The most common among them is gynecomastia. In this case, the male breasts begin to develop on a female basis, due to the accumulation of fat in the nipples.
They are easily removed surgically, but there is nothing pleasant for men in this. It is also worth noting that a high content of oestrogen in the male body leads to an increased retention of fluid and fat. For bodybuilders, this situation is unacceptable. But a way out of this situation exists – Anti-Oestrogen drugs. Which we will now talk a bit about.
The work of anti-oestrogens
Before proceeding to the description of the drugs themselves and determining the best of them, you should understand the mechanism of their effect on the body. Most often the process of aromatization proceeds as follows. The molecule of the anabolic drug, entering the body, is in a free state and begins to interact with the enzyme molecule – aromatase. As a result of this interaction, the steroid is converted into oestrogen.
The obtained molecule of oestrogen interacts with the receptor of the oestrogenic type, thus causing a certain effect. The result of this effect is influenced by the place where the receptor interacting with the molecule of the created oestrogen is located. Receptors in the chest cause gynecomastia.
You can avoid this in two ways:
– Prevent the connection of the steroid and aromatase.
– Do not allow the created molecule of oestrogen to enter into interaction with the receptors.
Thus, all anti-oestrogen drugs can be divided into two groups, depending on their mechanism of action.
Those drugs that use the first method are called anti-aromatase drugs, they inhibit the action of enzymes by attaching drug molecules to them instead of testosterone. These are drugs such as Anastrozole, Letrozole and Exemestane, which are commonly taken during a cycle of steroids.
The second group are antagonists of oestrogen, which block the release of the enzyme into the body, thereby reducing the possibility of their interaction with oestradiol. This group includes substances such as Clomiphene Citrate (Clomid) and Tamoxifen. These are usually used after a steroid cycle in post-cycle therapy.
If you are unsure about which anti-oestrogen is best for you, consult a sports medicine professional, a trainer or our support team for advice. You can find a sufficient number of anti-oestrogen drugs for sale in our store which are all of high-quality and at affordable prices.