Every athlete knows the effect of aromatization. This is the process of converting substances with high androgenic activity to oestrogens. To put it more simply, almost all steroids are based on testosterone derivatives – the male sex hormone. It follows that each of these drugs has a certain degree of androgenic activity.
This entails a sharp increase of female hormones (oestrogens) in the male body, which leads to unpleasant side effects. The most common among them is gynecomastia. In this case, the male breasts begin to develop on a female basis, due to the accumulation of fat in the nipples.
They are easily removed surgically, but there is nothing pleasant for men in this. It is also worth noting that a high content of oestrogen in the male body leads to an increased retention of fluid and fat. For bodybuilders, this situation is unacceptable. But a way out of this situation exists – Anti-Oestrogen drugs. We will now talk a bit about them.
The work of anti-oestrogens
Before proceeding to the description of the drugs themselves and determining the best of them, one should understand the mechanism of their effect on the body. Most often the process of aromatization proceeds as follows. The molecule of the anabolic drug, entering the body, is in a free state and begins to interact with the enzyme molecule – aromatase. As a result of this interaction, the steroid is converted into oestrogen.
The obtained molecule of oestrogen interacts with the receptor of the oestrogenic type, thus causing a certain effect. The result of this effect is influenced by the place where the receptor interacting with the molecule of the created oestrogen is located. Receptors in the chest cause gynecomastia.
You can avoid this in two ways:
Prevent the connection of the steroid and aromatase.
Do not allow the created molecule of oestrogen to enter into interaction with the receptors.
Thus, all anti-aromatase drugs can be divided into two groups, depending on their mechanism of action. Those drugs that use the first method are called anti-aromatase drugs, and the second group – antagonists of oestrogen.